Murder on the Fly: Volume 2 is a thrilling mystery set in San Francisco in 1981, where danger lurks at every corner and appearances can be deceiving. The story begins with the suspicious suicide of a gay police officer found in a radical commune high above Berkeley. This chilling discovery comes alongside a looming pest outbreak that threatens to cost California a staggering ten billion dollars unless contained. As Riley, a former police detective turned exterminator, dives deeper into the investigation, he uncovers strange discrepancies surrounding the incident. The maggots found at the scene do not align with the policeman's time of death, and the seemingly peaceful hippies reveal a far darker side.

Riley's expertise in handling both two-legged and six-legged pests becomes crucial. An old flame brings him back into a web of danger as he seeks the mastermind behind the nation's most devastating insect outbreak. With the Medfly spreading uncontrollably, Riley faces the challenge of uncovering whether the crisis stems from a government conspiracy or a radical environmentalist plot. With crops turning to ruined, worm-infested messes, Riley and his dedicated team at Goat Hill Extermination strive to solve a series of gruesome murders, brutal kidnappings, and economic chaos. As the tension escalates, revenge becomes the driving force behind the violence, leading to a deadly battle of survival. Amid the rekindling of romance and the threat of terrorism, Riley braces himself for the harsh reality that the stakes have never been higher, and he just might get burned.