In order for vitamins to be utilized by the body they must first be converted into their active coenzyme forms. This more potent Coenzymated B-6 is in its active form and ready to go to work immediately. Pyridoxal-5 -Phosphate (PLP or P-5 -P) is the main metabolically active coenzyme form of vitamin B-6. It is primarily in the liver that P-5 -P is synthesized from pyridoxine with the help of enzymes that require B-2 zinc and magnesium for their activity. P-5 -P activates over 100 enzymes many of which are involved in the conversion of amino acids into the neurotransmitters dopamine norepinephrine and serotonin. P-5 -P is also required for the synthesis of the hemoglobin molecule and plays an important role in regulating homocysteine levels.