Physician developed. Active Ingredients: Purified Water; USP Sodium Chloride; USP Sodium Bicarbonate to Neutralize pH; The Solution Bag Within the Canister is Externally Pressurized by Nitrogen Uses: 3 special designed nozzles are available to deliver the finest and most gentle mist for nasal application, a special adapter for nasal and sinus large volume rinse and a special tip to give a stronger force for wound washing.