Growing up can be a bumpy road and it s no exception for Riley who is uprooted from her Midwest life when her father starts a new job in San Francisco. Like all of us Riley is guided by her emotions - Joy (Amy Poehler) Fear (Bill Hader) Anger (Lewis Black) Disgust (Mindy Kaling) and Sadness (Phyllis Smith). The emotions live in Headquarters the control center inside Riley s mind where they help advise her through everyday life. As Riley and her emotions struggle to adjust to a new life in San Francisco turmoil ensues in Headquarters. Although Joy Riley s main and most important emotion tries to keep things positive the emotions conflict on how best to navigate a new city house and school.