Manage your aches with Equate Extra Strength Acetaminophen Headache Relief Caplets. Equate Extra Strength Headache Relief Caplets temporarily relieve minor aches and pains due to a headache, cold, arthritis, toothache, muscular aches, and premenstrual and menstrual cramps. Each of these fast-acting caplets is formulated with 250 milligrams of acetaminophen, 250 milligrams of aspirin, a nonsteroidal anti-inflammatory, and 65 milligrams of caffeine to give you the headache relief you need to get back to your day. Fight back against aches and pains with Equate Extra Strength Headache Relief Caplets. Making the right health decisions can be challenging. With a complete range of products and simple solutions, Equate allows you to take care of your family with confidence.