The application of circuits and systems and engineering principles to problems in the medicine has led to the emergence of biomedical circuits and systems as an exciting and rapidly growing area of research. Nanotechnology provides new nano-structured materials with amazing properties. The properties offered by nanomaterials can be applied to develop advanced instrumentation for biomedical diagnostics and personalized therapy as well as bio-sensing in the environment. Biotechnology provides new biochemical materials with novel properties to be applied to develop new performances in sensing techniques. These advancements in Nano- and Bio- technologies will lead to new concepts and applications for nano-bio-sensing systems. This book offers an invaluable reference to the state-of-the-art applications of nano-bio-sensing. It brings together expertise of researchers from the fields of nano-electronics and bio-technology providing multidisciplinary content from nano-structures fabrication to bio-sensing applications.