Zegerid OTC is an over the counter acid reducer. When used as directed, you can eliminate the burning, painful symptoms associated with frequent heartburn. Featuring omeprazole to tackle stomach acid and sodium bicarbonate to aid absorption of omeprazole, Zegerid OTC can combat frequent heartburn. When stomach acid backs up into your esophagus causing heartburn, turn to Zegerid OTC acid reducer. *Use as directed for 14 days for treating frequent heartburn. Zegerid OTC may take 1-4 days for full effect, although some people get relief within 24 hours.