Extra Strength Pain Reliever Excedrin Extra Strength Caplets are pain relievers that provide clinically proven, fast acting headache relief. These convenient Excedrin caplets work as hard as you do, combining aspirin and acetaminophen with caffeine. These active ingredients create a powerful formula with two pain fighters and a booster to offer temporary relief of pain from headaches, colds, premenstrual and menstrual cramps, arthritis, tooth pain and muscle pain. For some, headache pain relief with this Excedrin extra strength pain reliever can start in 15 minutes.